But the selection of total allowable error (TEa) is fundamental to this interpretation and harmonisation of the TEa calculation is needed.Īnalytical method evaluation Bias Biological variation Fitness for purpose Imprecision Sigma metrics.Ĭopyright © 2016 The Canadian Society of Clinical Chemists. A member of Beckman Coulters unique portfolio of scalable chemistry solutions, the AU680 is intended to help. Whereas, SM provided a summative evaluation of method performance. Olympus Beckman Coulter AU680 Chemistry Analyzer. The individual interpretation of bias and imprecision using FFP criteria allowed for the clear determination of the major source of error. There was some difference seen in interpretation for the other nine analytes. Comparing the quality processes eleven analytes produced a green light for both FFP and SM. The SM varied with analyte concentration with six analytes producing low Sigma values. Most analytes achieved at least minimum bias. The day-to-day imprecision of most tested analytes (except sodium and chloride) were smaller than the allowable imprecision (ranging from minimum to optimum).
#BECKMAN COULTER AU680 SERIES#
Depending on the user selection user can also view top products related to the selection. The newest member of the high-performance Beckman Coulter laboratory analyzer series is the AU680 Chemistry System. The outcomes of both quality approaches were then compared. Start typing, then use the up and down arrows to select an option from the list. The desirable total allowable error was determined from biological variation data and applied to the SM calculation.
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Standardization Standardized to the current AU480 and AU680 analyzers: same results, same sample racks. Biological variation data was used to calculate the minimum, desirable and optimal imprecision and bias for determination of FFP. Beckman Coulter - AU5800The Fastest AU Analyzer Ever., Building on the success of the AU platform, the AU5840 is the newest addition to Beckman Coulter’s family. Commercial external quality assurance (EQA) samples were used to determine the systematic error between the test method result and the instrument group mean result from the EQA program for each analyte. Twenty routine chemistry analytes were evaluated for imprecision and bias on the Beckman Coulter AU680 analyser. Third party commercial lyophilized internal quality control samples of human origin were used for day-to-day imprecision calculations. The Beckman Coulter AU680, designed for clinical chemistry laboratories, is an automated, multi-channel, selective analyser where the measurements are carried out using the spectrophotometry, turbidimetry and indirect ion. Twenty serum/plasma analytes were evaluated on the Beckman Coulter AU680.
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This study aimed to evaluate the imprecision and bias data generated for 20 routine chemistry analytes against both the biological variation fitness for purpose (FFP) and Sigma metrics (SM) criteria.